Semnan University Press Applied Chemistry Today 2981-2437 13 48 2018 09 23 Polyethylene Glycol (PEG-400): As Efficient Reaction Medium for the Synthesis of 1,5-Dihydropyrano[2,3-c]chromene Derivatives Polyethylene Glycol (PEG-400): As Efficient Reaction Medium for the Synthesis of 1,5-Dihydropyrano[2,3-c]chromene Derivatives 285 294 2985 10.22075/chem.2018.11349.1093 FA Mehdi Abaszadeh Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences Ali Asadipour Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran Journal Article 2017 05 16 In this research, a simple and effective method for the synthesis of 1,5-dihydropyrano[2,3-c]chromene multi-substituted derivatives has been introduced, using the three-component reaction of aromatic aldehydes, malononitrile and 3-hydroxycoumarin at room temperature and in the presence of polyethylene glycol (PEG-400) as solvent and reaction catalyst. Easy method, short reaction time, high atom economy, high yields, environmental acceptability and the easy of separating of polyethylene glycol are included as the most important advantages of this method. Moreover, the produced products were obtained through simple filtering and no need to column and technique chromatography with high purity. Moreover, the produced products were obtained through simple filtering and no need to column and technique chromatography with high purity. In this research, a simple and effective method for the synthesis of 1,5-dihydropyrano[2,3-c]chromene multi-substituted derivatives has been introduced, using the three-component reaction of aromatic aldehydes, malononitrile and 3-hydroxycoumarin at room temperature and in the presence of polyethylene glycol (PEG-400) as solvent and reaction catalyst. Easy method, short reaction time, high atom economy, high yields, environmental acceptability and the easy of separating of polyethylene glycol are included as the most important advantages of this method. Moreover, the produced products were obtained through simple filtering and no need to column and technique chromatography with high purity. Moreover, the produced products were obtained through simple filtering and no need to column and technique chromatography with high purity. https://chemistry.semnan.ac.ir/article_2985_275d7fb2fd45098ad5c3ece2ed4a2824.pdf