Semnan University Press Applied Chemistry Today 2981-2437 14 50 2019 03 21 Synthesis of new dipeptides based on uracil and thymine and investigation of the molecular docking of these compounds as inhibitors of quorum sensing system in Pseudomonas aeruginosa Synthesis of new dipeptides based on uracil and thymine and investigation of the molecular docking of these compounds as inhibitors of quorum sensing system in Pseudomonas aeruginosa 277 290 3292 10.22075/chem.2018.13316.1299 FA Azam Heidari zanjan university of medical sciences Nazila Valikhani Fard Department of Chemistry, Faculty of Science, University of Zanjan Nader Noshiranzadeh Department o chemistry, faculty of science, university of zanjan Rahman Bikas Department of chemistry , faculty of basic science, Imam Khomeini International University Journal Article 2017 12 16 In this study, due to the importance of dipeptide compounds in diagnosis of disease or as drug compounds, new dipeptide compounds were synthesized using pyrimidine derivatives of thymine and uracil. The reaction of Methyl 2- (5-methyl-2,4-dioxo-4,3-dihydropyrimidine-1 (2 H) -yl) acetate and methyl 2-2,4-dioxo-4,3-dihydropyrimidine -1 (2H) -Il) acetate with diamine derivatives lead to the production of dipeptide derivatives in good yield. Then, using the computational design of the drug by the molecular docking method, the inhibitory effect of synthetic compounds on the LasR regulatory protein of Pseudomonas aeruginosa quorum sensing system, which plays an important role in regulating the expression of pathogenic genes in bacteria, were investigated. The results of the study showed that synthetic compounds have a significant inhibitory effect on the LasR protein. In this study, due to the importance of dipeptide compounds in diagnosis of disease or as drug compounds, new dipeptide compounds were synthesized using pyrimidine derivatives of thymine and uracil. The reaction of Methyl 2- (5-methyl-2,4-dioxo-4,3-dihydropyrimidine-1 (2 H) -yl) acetate and methyl 2-2,4-dioxo-4,3-dihydropyrimidine -1 (2H) -Il) acetate with diamine derivatives lead to the production of dipeptide derivatives in good yield. Then, using the computational design of the drug by the molecular docking method, the inhibitory effect of synthetic compounds on the LasR regulatory protein of Pseudomonas aeruginosa quorum sensing system, which plays an important role in regulating the expression of pathogenic genes in bacteria, were investigated. The results of the study showed that synthetic compounds have a significant inhibitory effect on the LasR protein. https://chemistry.semnan.ac.ir/article_3292_ff22d774594b8982a56a8f0027f929d4.pdf