Semnan University Press Applied Chemistry Today 2981-2437 14 52 2019 09 23 Design of sensitive electrochemical sensor as the analytical tool for methyldopa in drug and biological samples Design of sensitive electrochemical sensor as the analytical tool for methyldopa in drug and biological samples 77 86 3742 10.22075/chem.2019.15076.1455 FA Maryam Abbasghorbani Gas Research Institute, Iran Oil Industry Research Institute, Tehran Journal Article 2018 06 20 In this work, an electrochemical sensor based on carbon paste electrode modified with Au nanoparticle and 1-methyl-3-octylimidazolium chloride was fabricated as a sensor for determination of methyldopa. Au nanoparticle synthesized by Nettle extract and characterized by UV-Vis and TEM methods. The modified electrode showed good electrical conductivity for methyldopa signal. The effect of pH showed that electro-oxidation of methyldopa occurred with two electrons and two protons. The fabricated sensor showed the dynamic range 0.08-550 μM with detection limit 0.04 μM for determination of methyldopa. In the final step, the fabricated sensor was used successfully for determination of methyldopa in tablet and urine samples. In this work, an electrochemical sensor based on carbon paste electrode modified with Au nanoparticle and 1-methyl-3-octylimidazolium chloride was fabricated as a sensor for determination of methyldopa. Au nanoparticle synthesized by Nettle extract and characterized by UV-Vis and TEM methods. The modified electrode showed good electrical conductivity for methyldopa signal. The effect of pH showed that electro-oxidation of methyldopa occurred with two electrons and two protons. The fabricated sensor showed the dynamic range 0.08-550 μM with detection limit 0.04 μM for determination of methyldopa. In the final step, the fabricated sensor was used successfully for determination of methyldopa in tablet and urine samples. https://chemistry.semnan.ac.ir/article_3742_2f7233700463f1c6473308cd46bffd94.pdf