Semnan University Press Applied Chemistry Today 2981-2437 16 60 2021 09 23 Extraction of Active Ingredients from Shiraz City Bitter Orange Peel with supercritical carbon dioxide and soxhlet Extraction of Active Ingredients from Shiraz City Bitter Orange Peel with supercritical carbon dioxide and soxhlet 123 138 5450 10.22075/chem.2021.20609.1876 FA Ali Zarei Department of Chemical Engineering, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran Nadia Esfandiari Department of Chemical Engineering, Marvdasht Branch, Islamic Azad University, Marvasht, Iran Journal Article 2020 08 26 In this study, two methods of soxhlet extraction and supercritical carbon dioxide extraction were used to extract the effective substances in bitter orange peel. In supercritical fluid extraction, the effect of operational parameters such as temperature, pressure, dynamic time and particle size at different levels on extraction efficiency was investigated. To investigate the more accurate effect of the parameters, the design of the experiment was carried out and the response method was used and a model was obtained for the percentage of extraction efficiency by changing the parameters. The extracted materials were compared with two methods. One of the most important extracted materials is ostol and limonene. The amount of ostol in oil extracted by supercritical carbon dioxide is significantly higher than soxhlet method. The best extraction conditions with supercritical carbon dioxide, dynamic time of 80 minutes, temperature of 35 °C, pressure of 157.26 bar and particle size of 0.4099 mm were obtained. In this study, two methods of soxhlet extraction and supercritical carbon dioxide extraction were used to extract the effective substances in bitter orange peel. In supercritical fluid extraction, the effect of operational parameters such as temperature, pressure, dynamic time and particle size at different levels on extraction efficiency was investigated. To investigate the more accurate effect of the parameters, the design of the experiment was carried out and the response method was used and a model was obtained for the percentage of extraction efficiency by changing the parameters. The extracted materials were compared with two methods. One of the most important extracted materials is ostol and limonene. The amount of ostol in oil extracted by supercritical carbon dioxide is significantly higher than soxhlet method. The best extraction conditions with supercritical carbon dioxide, dynamic time of 80 minutes, temperature of 35 °C, pressure of 157.26 bar and particle size of 0.4099 mm were obtained. https://chemistry.semnan.ac.ir/article_5450_a4b55d6742499d0dca172b536dc84387.pdf