Semnan University Press Applied Chemistry Today 2981-2437 4 13 2009 11 22 Synthesis of Cefuroxime antibiotic precursor:[(6R,7R)-7-[2-furanyl-(z)-2-methoxyimino] acetamido-3-hydroxymethyl-3-cephem-4-carboxylic acid Synthesis of Cefuroxime antibiotic precursor:[(6R,7R)-7-[2-furanyl-(z)-2-methoxyimino] acetamido-3-hydroxymethyl-3-cephem-4-carboxylic acid 68 74 564 10.22075/chem.2017.564 FA Yaghoub Sarrafi Kamal Alimohammadi Khadijeh Alipour Journal Article 2017 01 15 Synthesis of 3-hydroxy cefuroxime antibiotic has been reported using 7-aminocephalosporanic acid (7-ACA) and 2-furanyl-Z-2-methoxy iminoacetic acid salt. Synthesis of this compound was carried out in three steps with good yield omitting acetyl group or in fact hydrolysis of 7-aminocephalosporanic acid (7-ACA) to produce 7-amino-3-hydroxy methyl cephalosporanic acid and then chlorination of 2-furanyl-Z-2-methoxy imino acetic acid salt by phosphorus pentachloride and finally coupling of 7-amino-3-hydroxy methyl cephalosporanic acid and 2-furanyl-Z-2-methoxy imino acetyl chloride. Synthesis of 3-hydroxy cefuroxime antibiotic has been reported using 7-aminocephalosporanic acid (7-ACA) and 2-furanyl-Z-2-methoxy iminoacetic acid salt. Synthesis of this compound was carried out in three steps with good yield omitting acetyl group or in fact hydrolysis of 7-aminocephalosporanic acid (7-ACA) to produce 7-amino-3-hydroxy methyl cephalosporanic acid and then chlorination of 2-furanyl-Z-2-methoxy imino acetic acid salt by phosphorus pentachloride and finally coupling of 7-amino-3-hydroxy methyl cephalosporanic acid and 2-furanyl-Z-2-methoxy imino acetyl chloride. https://chemistry.semnan.ac.ir/article_564_d23f7497922df00db1ee84991cd17290.pdf