Semnan University Press Applied Chemistry Today 2981-2437 18 66 2023 03 21 Synthesis, Characterization and DNA binding studies of Platinum Complexes with Imine Ferrocene Ligand Synthesis, Characterization and DNA binding studies of Platinum Complexes with Imine Ferrocene Ligand 225 240 7562 10.22075/chem.2022.25045.2021 FA Behnam Habibi Shabestary Department of Inorganic Chemistry, Faculty of Chemistry and petroleum sciences, Shahid Behehshti University, Tehran, Iran Mohsen Golbon Haghighi Department of Inorganic Chemistry, Faculty of Chemistry and petroleum sciences, Shahid Behehshti University, Tehran, Iran 0000-0002-2422-9075 Journal Article 2021 11 10 In this manuscript,, the synthesis and characterization by NMR spectroscopy of the two novel platinum complexes with the imine ferocene with different coordination mode to platinum center, Pt(Cl)2(dmso)(Imine) (1) and Pt(Me)(dmso)(Imine) (2) was introduced , in which the ligand was attached as the monodentate ligand in (1) and in (2) the ligand was attached as the cyclomatalated bidentate ligand , were introduced for checking their anticancer properties. Also their interaction waith DNA was studied by UV-Vis titration technique. In addition, Molecular docking simulation by Schrödinger sofware was used for checking the various possible attachment mode of their interaction with DNA. In this manuscript,, the synthesis and characterization by NMR spectroscopy of the two novel platinum complexes with the imine ferocene with different coordination mode to platinum center, Pt(Cl)2(dmso)(Imine) (1) and Pt(Me)(dmso)(Imine) (2) was introduced , in which the ligand was attached as the monodentate ligand in (1) and in (2) the ligand was attached as the cyclomatalated bidentate ligand , were introduced for checking their anticancer properties. Also their interaction waith DNA was studied by UV-Vis titration technique. In addition, Molecular docking simulation by Schrödinger sofware was used for checking the various possible attachment mode of their interaction with DNA. https://chemistry.semnan.ac.ir/article_7562_eb46c61f91aab8c2b002b288485fc118.pdf