Synthesis, characterization and biological studies complexes of Co(II), Ni(II), Cu(II) and Cd(II) with 5-(2-pyridyl)-2-(3,5-dinitro benzen)-1,3,4- oxadiazole ligand on McCoy cell

Bezaatpour, Abolfazl; Adeli, Adel; Mansoori, Yaghob; Zahri, Saber; Amiri, Mandana

doi:10.22075/chem.2017.587

Synthesis, characterization and biological studies complexes of Co(II), Ni(II), Cu(II) and Cd(II) with 5-(2-pyridyl)-2-(3,5-dinitro benzen)-1,3,4- oxadiazole ligand on McCoy cell

Authors

Abolfazl Bezaatpour

Adel Adeli

Yaghob Mansoori

Saber Zahri

Mandana Amiri

10.22075/chem.2017.587

Abstract

In this research we report new complexes with the formula 5-(2-pyridyl)-2-(3,5-dinitro benzen)-1,3,4- oxadiazole ligand with Co(II), Ni(II), Cu(II) and Cd(II). These complexes were synthesized and characterized by IR spectroscopy, electronic spectroscopy, atomic absorption spectroscopy (AAS) , atomic absorption and elemental analysis and physical properties. In these complexes the oxadiazole bidentate ligands links to the metal ion through the Npyridine and one of the Noxadiazole atoms. This result trials showed that stoichiometry ratio of L/M in primary material do not significantly depend on the products the ligand-to-metal ratio. The biological activity of complexes was studied on McCoy cell line. The biological data of antioxidant activity by these complexes on McCoy cells imply that complexes inhibit the McCoy viability. Morphological studies showed significant change of treated cell shape.

Keywords

Co(II) complex

Ni(II) complex

Cu(II) complex

Cd(II) complex

oxadiazole

MTT assay

McCoy cell