Synthesis of Montelukast using dichloroimidazolidinedione (DCID)

Document Type : Original Article

Authors

1 Department of Chemistry, Science and Research Branch, Islamic Azad University, Tehran, Iran

2 Chemistry & chemical Engineering Research Center of Iran, Tehran, Iran

Abstract

In this paper, a modified and scalable method for the preparation of montelukast (Singulair, a famous drug demonstrated for the chronic and prophylaxis therapy of asthma) is presented based on a new and useful method for performing substitution reactions. The process of preparing montelukast by this method is a practical and economical method, and minimize an amount of impurities and lets the efficient production of montelukast and its scale-up. In this study, the synthesis of montelukast using a new reagent called dichloro imidazolidine dione (DCID) to activate the C-O bond of alcohols has been investigated. Dichloroimidazolidine dione (DCID) alone promoted the reactions and no additional metal catalyst was required. The structures of the synthesized compounds were identified using the comparison of melting point and NMR spectra. The innovation of the present work is related to the application of DCID for the first time to activate the C-O bond of alcohols and use in the relevant reactions.

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Applied Chemistry Today
Volume 20, Issue 76
September 2025
Pages 65-74

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