Electrochemical measurement of the anticancer drug epirubicin in injection and serum samples using a carbon paste electrode modified with NiO/carbon nanotube nanocomposite

Karimi-Maleh, Hassan; Zare, Najmeh

doi:10.22075/chem.2026.36848.2343

Electrochemical measurement of the anticancer drug epirubicin in injection and serum samples using a carbon paste electrode modified with NiO/carbon nanotube nanocomposite

Document Type : Original Article

Authors

Hassan Karimi-Maleh ¹

Najmeh Zare ²

¹ School of Chemistry, Damghan University, Damghan 36716-45667, Iran

² School of Resources and Environment, University of Electronic Science and Technology of China, Chengdu, China

10.22075/chem.2026.36848.2343

Abstract

In this research work, NiO/carbon nanotube nanocomposite (NiO/CNTs) was synthesized using direct deposition method and characterized using Transmission electron microscopy (TEM) and elemental analysis (EDS). Then, carbon paste electrode modified with NiO/CNTs nanocomposite with optimal weight percentage (10% w/w) was prepared and the designed sensor was used to investigate the electrochemical behavior of epirubicin. The results showed that the highest sensitivity was achieved under neutral conditions. The designed sensor detected epirubicin well in the concentration range of 0.01-320 μM and a detection limit of 8 nM was obtained for the measurement of epirubicin on the surface of the new sensor. The modified sensor has shown good catalytic ability in increasing the oxidation current as well as reducing the drug overvoltage. Finally, the proposed sensor was used to measure epirubicin in injection and dextrose saline samples and the results showed a recovery percentage of 97.4%-102.8%, which is acceptable for a new sensor.

Keywords

Epirubicin

Modified Electrode

NiO/CNTs nanocomposite

Sensor

Subjects