Investigation of antifungal and antioxidant activity of nanoemulsions prepared from essential oil of the Gandevash

Document Type : Original Article

Authors

1 Department of Organic Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran

2 Department of Parasitology and Mycology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran

10.22075/chem.2026.40049.2418

Abstract

Dandruff is one of the most common skin problems and the role of Malassezia furfur in its occurrence is well known. In this study, Artemisia annua (Gandevash) essential oil was prepared in the form of three nanoemulsion formulations and their stability was evaluated under different environmental conditions including centrifugation, heat, cold, pH and ionic strength. Then, the antifungal activity against M. furfur was investigated. Also, the antioxidant activity of the nanoemulsions was compared with the essential oil. Stability evaluation of the three nanoemulsion formulations of Artemisia annua essential oil showed that nanoemulsion number 1 and 2 had the lowest absorption and turbidity in ionic, thermal, pH change and centrifugation stability tests and was more stable than the nanoemulsion number3. Nano 3 also showed the highest instability in all tests. The antioxidant test results showed that nanoemulsion 3 with IC50 equal to 1.2636±0.0001 mg/ml had greater antioxidant power than the essential oil with IC50 equal to 9.0589±0.0001 mg/ml. On the other hand, only nanoemulsion 2 was able to inhibit the growth of M. furfur and its MIC was significantly lower than that of the pure essential oil; which confirms the role of emulsion nanoparticles in improving the release and effectiveness of active compounds. Overall, this study shows that the optimized nanoemulsion of gandevash essential oil can be a natural and effective option for controlling fungal agents associated with dandruff and has significant potential for the development of herbal therapeutic formulations

Keywords

Main Subjects

Applied Chemistry Today
Volume 21, Issue 78
May 2026
Pages 111-138

Files

Share

How to cite

Statistics