Fabrication of a Sensitive Electrochemical Sensor for Determination of Carbamazepine in Human Plasma Using ZSM-5 Nanozeolite

Document Type : Original Article



Carbamazepine (CBZ) is an anticonvulsant drug used in the treatment of epilepsy. However, the HPLC technique for determination of CBZ has advantages of accuracy and excellent resolution, the cost of the equipment, time-consuming steps and high maintenance limit its application. In this work, we have developed a new electrochemical sensor for the determination of CBZ. In this research, modified carbon past electrode (CPE) was fabricated by ZSM-5 nanozeolite, graphite powder and paraffin oil. Then, the electrochemical oxidation of the modified electrode towards the oxidation of CBZ investigated by voltammetric methods. Differential pulse voltammetry (DPV) peak currents increased linearly with concentrations of CBZ at the ranges of 0.35-95 µM with detection limits of 0.1 µM. The fabricated ZSM-5/CPE was provided an excellent sensor for the determination of CBZ with good reproducibility and recovery and very low detection limit. The method has been applied to the determination of CBZ in real pharmaceutical dosage forms such as human plasma and can be used in samples of hospital.


[1] E. Pretorius, H. Klinker and B. Rosenkranz, Therapeutic drug monitoring, 33 (2011) 265-274
[2] M. Dalby, Epilepsia, 12 (1971) 325.
[3] W. Schindler and F. Häfliger, Helvetica Chimica Acta, 37 (1954) 472.
[4] R. H. Mattson, Epilepsia, 36 (1995) S22.
[5] E. Doods LJ. Drugs in Use: Clinical Case Studies for Pharmacists,  London, Pharmaceutical Press, (2010).
[6] O. Guneysel, O. Onur, A. Denizbasi and M. Saritemur, Journal of Medical Case Reports, 2 (2008) 242.
[7] J. M. Pellock, Epilepsy & Behavior, 3 (2002) S14.
[8] T. Takayasu, Y. Ishida, A. Kimura, M. Nosaka, Y. Kuninaka, M. Kawaguchi and T. Kondo, Forensic Toxicology, 28 (2010) 124.
[9] A. Gürses, Ç. Doğar, M. Yalçın, M. Açıkyıldız, R. Bayrak and S. Karaca, Journal of Hazardous Materials, 131 (2006) 217.
[10] K. A. Khatamian M, Haghighi M, Ghadiri M. , Appl. Surf. Sci., 258 (2011) 865.
[11] S. K. H. Nejad-Darzi, A. Samadi-Maybodi and M. Ghobakhluo, Journal of Porous Materials, 20 (2013) 909.
[12] N. Viswanadham, S. K. Saxena, J. Kumar, P. Sreenivasulu and D. Nandan, Fuel, 95 (2012) 298.
 [13] ج. محمودی, م. ن. لطف اللهی , ع. حقیقی اصل, مجله شیمی کاربردی (اندیشه علوم), شماره 31 (1393) ص 19.
[14] ب. محمدخانی، م. حقیقی ، ع. آقایی, مجله شیمی کاربردی (اندیشه علوم), شماره 39 (1395) ص 65.
 [15] A. Patterson, Physical Review, 56 (1939) 978.
[16] M. Khatamian, S. Hashemian and S. Sabaee, Materials Science in Semiconductor Processing, 13 (2010) 156.
[17] N. F. Zainudin, A. Z. Abdullah and A. R. Mohamed, Journal of Hazardous Materials, 174 (2010) 299.
[18] A. Veiga, A. Dordio, A. P. Carvalho, D. M. Teixeira and J. G. Teixeira, Analytica Chimica Acta, 674 (2010) 182.
[19] S. S. Kalanur, S. Jaldappagari and S. Balakrishnan, Electrochimica Acta, 56 (2011) 5295.
[20] R. R. Mashhadizadeh MH, Amereh E., Analytical and Bioanalytical Electrochemistry3 (2013) 270.
[21] R. Jain, D. C. Tiwari and S. Shrivastava, Materials Science and Engineering: B, 185 (2014) 53.
[22] L.-H. Liu, C.-Q. Duan and Z.-N. Gao, Journal of the Serbian Chemical Society, 77 (2012) 483.
[23] N. P. Trišović, B. Đ. Božić, S. D. Petrović, S. J. Tadić and M. L. Avramov-Ivić, Hemijska Industrija, 68 (2014) 207.
[24] S. Atkins, J. Gonzalez-Rodriguez, J. Sevilla, M. Blazquez, T. Pineda and R. Jimenez-Perez, International Journal of Electrochemical Science, 8 (2013) 2056.
[25] B. Unnikrishnan, V. Mani and S.-M. Chen, Sensors and Actuators B: Chemical, 173 (2012) 274.