Interaction of Vanadil Schiff base Complexes with DNA of Timothy Calves by Ultraviolet-Visage Spectroscopy, Fluorescence Spectrometry and their Antibacterial Properties

Document Type : Original Article


1 Faculty of chemistry, Semnan University, Semnan, Iran

2 Faculty member of Semnan University

3 School of Chemistry, Damghan University, Damghan, Iran

4 School of Chemistry, Damghan University, Damghan , Iran


In this study, the interaction of Schiff base Exo-Vanadium Complexes from salicylidine derivatives with cytomegalovirus DNA (ct-DNA) was investigated by ultraviolet-spectroscopy and fluorescence spectroscopy. Using the results of these empirical studies, the coupling mechanism between the two chlorine derivatives and the bromo derivative of the schiff base complexes with DNA, the constant binding of the ligand to the DNA, and the number of binding sites (n) were investigated. The fixed binding values ​​(kb) and (kf) obtained from ultraviolet-light spectroscopy studies and fluorescence spectroscopy for Chromine derivatives are larger than the Barmox derivative, which suggests further interactions between the chlorine complex and DNA. The antimicrobial activity of the Schiff base Vanadil Complex, on the gram-positive bacteria of Staphylococcus aureus and the worm-negative bacteria of Escherichia coli, was studied and compared with the standard antibacterial materials. Based on the results, both schiff base vanadium complexes of the study are approximately equal to the amount of good antibacterial activity, with the difference that the derivative contains a functional group of chlorine has more antibacterial activity than the derivative containing the bromine functional group against the bacteria Is negative. From these observations, it can be concluded that the antibacterial activity of these complexes is related to the presence of Cl and Br substituents.


Main Subjects

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