Voltammetric determination of benserazide using electrochemical sensor modified with CoFe2O4 and ionic liquid in pharmaceutical and biological samples

Document Type : Original Article


1 Department of basic science, Faculty of Engineering, Bushehr Branch, Islamic Azad University, Bushehr, Iran

2 Department of Chemical Engineering, Laboratory of Nanotechnology, Quchan University of Technology, Quchan, Islamic Republic of Iran

3 Department of Chemistry, University of Mohaghegh Ardabili, Ardabil, Iran


A modified electrochemical sensor based on carbon paste electrode modified with CoFe2O4 nanoparticle and 1-Butyl-3-methylimidazolium tetrafluoroborate was fabricated for benserazide determination. In the first step, CoFe2O4 nanoparticle were synthesized by co-precipitation method and characterized by TEM method. In continuous and at optimum condition, the prepared sensor showed dynamic range between 0.1-350.0 μM with detection limit 0.05μM for determination of benserazide. The diffusion coefficient was determined by chronoamperometric method. The proposed sensor showed good selectivity for determination of benserazide in the presence of usual interferences. Finally, the modified sensor was used for determination of benserazide in pharmaceutical and biological samples and showed the high ability for analysis of this drug in real samples.


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