An effective and efficient method for the synthesis of pyrazole-fused isocoumarins by the recyclable magnetic solid acid γ-Fe2O3-SO3H under solvent-free condition

Document Type : Original Article

Authors

semnan university

Abstract

A novel and effective method in order to improvement of synthesis of pyrazole-fused isocoumarins from available materials such as ninhydrin and arylhydrazones was consider in this paper. A variety of substituted pyrazole-fused isocoumarin were synthesized by a one-pot reaction of ninhydrin and arylhydrazone in ecxellent yields under solvent-free conditions. In this reactions γ-Fe2O3-SO3H was used as, reusable, green and efficient catalyst. The attractive advantages of this method are the high yields, mild condition and reusability of the catalyst. The pyrazole-fused isocoumarin derivatives have a wide range of biological activities such as antimicrobial, antimalarial, and some of them are known as GABA receptor.

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References

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Applied Chemistry Today
Volume 15, Issue 54
March 2020
Pages 205-216

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