Design and construction of molecularly imprinted polymer as adsorbent for inulin solid phase extraction

Document Type : Original Article


1 Faculty of Basic Sciences, Department of Chemistry, Golestan University, Gorgan, Iran

2 Department of Basic Sciences, Farhangian University, Tehran, Iran


Molecular imprinted polymer (MIP) technology is a highly efficient method of separating impurities and enhancing the quality and purity of pharmaceutical and food raw materials because of its advantages such as high selectivity, chemical stability and low cost. In the present study, theMIP as a selective adsorbent on the target molecule was synthesized by free-radical polymerization, mass and noncovalent methods. In this polymer, methacrylic acid (monomeric agent), -N', N'Methylene-bis-acrylamide(MBAAm) (crosslinking agent), ammonium persulfate (initiator), inulin (target molecule) and water (solvent) were used. To compare the polymer performance, a not-imprinted polymer(NIP) was synthesized under the same conditions without the use of the target molecule. The structure of the synthesized polymers was confirmed by Fourier transform infrared(FT-IR) spectroscopy. The polymer porosity was calculated to be 43.4%. The selectivity of the MIP for adsorption of the target molecule was investigated through adsorption experiments and its results were compared with the adsorption of the target molecule by NIP. Moreover, various parameters such as pH, time, sample concentration and ionic strength were optimized. The results of the experiments showed that at pH = 4 after 15 minutes the amount of inulin uptake will be 137.142.


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