p-Toluenesulfonyl Chloride (p-TsCl) as a New and Effective Catalyst for Acetylation and Formylation of Hydroxyl Compounds under Mild Conditions

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Abstract

The first catalytic application of p-TsCl for efficient acetylation of various types of alcohols and phenols with acetic anhydride in both solution and solvent-free conditions is reported. Also structurally diverse alcohols were formylated using formic acid based on the use of catalytic amount of p-TsCl under solvent-free condition. The reactions were carried out in short reaction time and in good to excellent yields at room temperature.

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