Controlled drug release is one of the most important methods to increase the therapeutic effects and decrease side effects of drug. In this research, three drugs (piperazine, 8-aminoquinoline, N-phenyl piperazine) were attached chemically to the p-styrene sulphonyl chloride (as monomer), and they were polymerized by AIBN ( Azobis isobutyro nitrile) at 80 °C. Finally, release ability of three polymer-drugs were tested in buffer solution with pH= 1.3 at the temperature 37 °C. The GPC spectra of the polymers showed that polymerization of monomers containing drugs were carried out. The results established that, these polymeric systems are able to release drugs.
Khazaei, A., Amini Manesh, A., & Golbaghi, M. (2012). Synthesis and application of some Drug-conjugated Poly p-styrene sulphonate for drug release Delivery. Applied Chemistry Today, 7(23), 11-19. doi: 10.22075/chem.2017.604
MLA
Ardeshir Khazaei; Abbas Amini Manesh; Maryam Golbaghi. "Synthesis and application of some Drug-conjugated Poly p-styrene sulphonate for drug release Delivery", Applied Chemistry Today, 7, 23, 2012, 11-19. doi: 10.22075/chem.2017.604
HARVARD
Khazaei, A., Amini Manesh, A., Golbaghi, M. (2012). 'Synthesis and application of some Drug-conjugated Poly p-styrene sulphonate for drug release Delivery', Applied Chemistry Today, 7(23), pp. 11-19. doi: 10.22075/chem.2017.604
VANCOUVER
Khazaei, A., Amini Manesh, A., Golbaghi, M. Synthesis and application of some Drug-conjugated Poly p-styrene sulphonate for drug release Delivery. Applied Chemistry Today, 2012; 7(23): 11-19. doi: 10.22075/chem.2017.604
)