Controlled drug release is one of the most important methods to increase the therapeutic effects and decrease side effects of drug. In this research, three drugs (piperazine, 8-aminoquinoline, N-phenyl piperazine) were attached chemically to the p-styrene sulphonyl chloride (as monomer), and they were polymerized by AIBN ( Azobis isobutyro nitrile) at 80 °C. Finally, release ability of three polymer-drugs were tested in buffer solution with pH= 1.3 at the temperature 37 °C. The GPC spectra of the polymers showed that polymerization of monomers containing drugs were carried out. The results established that, these polymeric systems are able to release drugs.
Khazaei,A , Amini Manesh,A and Golbaghi,M . (2012). Synthesis and application of some Drug-conjugated Poly p-styrene sulphonate for drug release Delivery. Applied Chemistry Today, 7(23), 11-19. doi: 10.22075/chem.2017.604
MLA
Khazaei,A , , Amini Manesh,A , and Golbaghi,M . "Synthesis and application of some Drug-conjugated Poly p-styrene sulphonate for drug release Delivery", Applied Chemistry Today, 7, 23, 2012, 11-19. doi: 10.22075/chem.2017.604
HARVARD
Khazaei A, Amini Manesh A, Golbaghi M. (2012). 'Synthesis and application of some Drug-conjugated Poly p-styrene sulphonate for drug release Delivery', Applied Chemistry Today, 7(23), pp. 11-19. doi: 10.22075/chem.2017.604
CHICAGO
A Khazaei, A Amini Manesh and M Golbaghi, "Synthesis and application of some Drug-conjugated Poly p-styrene sulphonate for drug release Delivery," Applied Chemistry Today, 7 23 (2012): 11-19, doi: 10.22075/chem.2017.604
VANCOUVER
Khazaei A, Amini Manesh A, Golbaghi M. Synthesis and application of some Drug-conjugated Poly p-styrene sulphonate for drug release Delivery. Applied Chemistry Today. 2012;7(23):11-19 (In Persian). doi: 10.22075/chem.2017.604
