Nano-Fe3O4 catalyzed synthesis of 3-aminoalkylated indoles and evaluation of their antibacterial activities



Indoles are one of the most prevalent heterocyclic compounds, which are present as the basic cores in many natural products potent pharmaceutical compounds. Despite numerous diverse approaches toward the synthesis of indoles developed so far, it is still challenging to prepare indoles with various substituents from readily available compounds. In this approach, nano-Fe3O4 been applied as a catalyst for one-pot synthesis of 3-aminoalkylated indoles in solvent-free conditions. This method offers some advantages in terms of short reaction times, easy work-up procedure, high yields and mild conditions. These products were evaluated in vitro for their antibacterial activities.