Phosgene-free preparation of primary carbamates and Boc-protection of amine using H2SO4-Silica under solvent free conditions



An efficient and mild method for the preparation of primary carbamate from alcohols and phenols using sodium cyanate and Boc-protection of amine in the presence of H2SO4-Silica was demonstrated. The reactions were carried out under solvent free conditions. These methods are simple, effective and environmentally friendly and have the advantage of good to excellent yields.