Anti-bacterial screening and sequential synthesis of 1,2,3-triazoles ‎from alcohols and epoxides in water

Document Type : Original Article

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Abstract

The triazole core is an important part of the therapeutically drugs such as antimicrobial, analgesic and anti-inflammatory agents. Therefore, a facile synthesis of a series of 1,2,3-triazoles has been introduced by the sequential azidation of alcohols or epoxides and then Cu (I)-catalyzed azide-alkyne cycloaddition (CuAAC) in water. The biological profiles of some of these five-membered heterocyclic scaffolds toward anti-bacterial activities were evaluated using Kirby-Bauer Disc Diffusion method. The biological obtained results were very interesting and revealed that most of the examined molecules are potent antibacterial agents when compared with standard drugs.

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References

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Applied Chemistry Today
Volume 12, Issue 42
March 2017
Pages 9-22

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