Preparation, characterization and determination of antibacterial effects of zeolitic imidazolium frameworks coated by hyaluronic acid against methicillin-resistant Staphylococcus,, Pseudomonas aeruginosa, and Escherichia coli bacterial strains

Document Type : Original Article

Authors

1 Department of Pharmaceutical Nanotechnology, School of pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran

2 Department of Pharmaceutical NanotechnologySchool of PharmacyZanjan University of Medical Sciences, Zanjan, Iran

3 Department of Microbiology, school of Medicine, zanjan university of medical sciences, zanjan, Iran

Abstract

Objectives: Antibiotic resistance remain a major health challenge that threatens the lives of many people. Recent studies shows that metal nanoparticles, including zeolitic imidazolate frameworks, have good antibacterial properties. In this project, we attempted to synthesize a microporous nanoparticle called ZIF-8 (a subset of a large family of zeolitic imidazolate frameworks) and then functionalized it with silver and hyaluronic acid. It was found that such functionalization could improve antibacterial properties ZIF-8.
Methods: ZIF-8 and ZIF-8/Ag@ZIF-8 were characterized thorough N2 adsorption-desorption analysis, Fourier transform infrared (FT-IR) spectroscopy, powder X-ray diffraction (PXRD), and scanning electron microscope (SEM). antibacterial properties ZIF-8 and ZIF-8/Ag@ZIF-8 against Methicillin-Resistant Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli was assessed by method of Microbroth dilution.
Results: Results demonstrated coating of ZIF-8 with Ag and HA could significantly improve antibacterial properties ZIF-8 against Methicillin-Resistant Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli .
Conclusion: We believe that our findings demonstrate that the use of functionalized zeolitic imidazolate frameworks can be as excellent alternative candidates against bacterial infections.

Keywords

Main Subjects

This is an open access article under the CC-BY-SA 4.0 license.( https://creativecommons.org/licenses/by-sa/4.0/)

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Applied Chemistry Today
Volume 18, Issue 68
September 2023
Pages 161-176

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