Synthesis and identification of magnetic nickel oxide nanoparticles for the magnetic solid phase extraction of gemfibrozil and its determination by UV-Vis spectrometer.

Document Type : Original Article

Authors

Tehran Islamic Azad University of Medical Sciences, Faculty of Medicinal Chemistry, Department of Chemistry, Tehran, Iran, PO Box: 1913674711

Abstract

In the presented method, modified magnetic nickel oxide was synthesized and identified for pre-concentration and determination of gemfibrozil in human serum samples, pharmaceutical wastewater and drug. Fourier transform infrared spectrum (FTIR), X-ray diffraction (XRD) and scanning electron microscope (SEM) were used to identify magnetic nickel oxide nanoparticles. Some parameters affecting the extraction, including pH effect, amount and type of elution solvent, extraction time, etc., were optimized and investigated. The concentration factor was 120, the limit of detection (LOD) was 0.16 µg.L-1, and the linear range of the calibration curve was 0.05 to 10 µg.L-1. The adsorption capacity was 52.69 mg.g-1. This method was successfully used to determination of gemfibrozile in human serum samples, pharmaceutical wastewater and drug using UV-Vis spectrometer with recovery in the range of 0.98-0.104%. Then, the samples determined by the proposed method with the results of the standard high-performance liquid chromatography (HPLC) method were compared. The results were checked with T-test and showed that there is no significant difference between the two methods.

Keywords

Main Subjects

This is an open access article under the CC-BY-SA 4.0 license.( https://creativecommons.org/licenses/by-sa/4.0/)

References

[1] Abniki, M., Moghimi, A., Azizinejad, F. (2020). Fabrication of bionanocomposite based on LDH using biopolymer of gum arabic and chitosan-coating for sustained drug-release. J  Serb Chem Soc, 85 (9), 1223-1235.
[2] Rao,T. N., Babji, P., Ahmad, N., Khan, R. A., Hassan, I., Shahzad, S. A., Husain, F. M. (2019). , Green synthesis and structural classification of Acacia nilotica mediated-silver doped titanium oxide (Ag/TiO2) spherical nanoparticles: Assessment of its antimicrobial and anticancer activity. Saudi J Biol Sci 26, 1385-1391.
[3] Roskati, A.A., Jangali, M. A. C., Godarzi, N., Bagherian, G., Salami. M. (1396). , modified glassy carbon electrode with multi-walled carbon nanotubes and polyalizarin red as a new voltammetric sensor for fibrosil gem measurement. Nano material, 29, 23-36. (in Persian) 
[4] Craig, C.R., Stitzel, R.E. (2004). Modern pharmacology with clinical applications. Lippincott Williams & Wilkins.
[5] Shahtaheri, S.J., Ghamari, F., Golbabaei, A., Rahimi Froushani, A., Abdollahi, M. (2005). Sample preparation followed by high performance liquid chromatographic (HPLC) analysis for monitoring muconic acid as a biomarker of occupational exposure to benzene. Int JOSE, 11, 377-388.
[6] Shahtaheri, S.J., Khadem, M., Golbabaei, F., Rahimi-Froushan, A., Ganjali, M.R., Norouzi, P. (2007). Solid phase extraction for evaluation of occupational exposure to Pb (II) using XAD-4 sorbent prior to atomic absorption spectroscopy. Int JOSE, 13, 137-145.
[7] Khadem, M., Golbabaei, F., Rahimi Froushani, A., Shahtaheri, S.J. (2010). Optimization of Solid Phase Extraction for trace determination of cobalt (II) using chromosorb 102 in biological monitoring. IJOH, 2, 10-16.
[8] Purjavid, M., Rezaei, M., Yusefi, S. R., Haji Hoseini, M., Moazami, H., Tabib Zadeh Dezfuli, S. (1401). Synthesize and modification of nano graphene oxide as solid phase adsorbent for separation and preconcentration of Iron (III) and Zinc ions from foods, soil and biological. JAC, 64, 89-104. (in Persian) 
[9] Wang, B., Zhu, Y., Bai, Z., Luque, R., Xuan, (2017). Functionalized chitosan biosorbents with ultra-high performance, mechanical strength and tunable selectivity for heavy metals in wastewater treatment. J Chem Eng, 325, 350-359.
[10] Moghimi, A., Alborji, A., Qomi, M., Ardakan,H. A. (2020). An alternative method of extracting of trace Hg (II) in water samples using Fe3O4@ quillaja Sapogenin on Ambersorb 572 and determination by CVAAS. Arch Pharm Pract, 14, 79-90.
[11] Nabavi, S. R, Shamsi, M. (2018). Preparation and characterization of polyaniline/graphene oxide nanocomposite and its assessment for removal of chromium (VI) from aqueous media. JAC, 17, 29-41. (in Persian) 
[12] Simpson, N., Dekker, M. (1997). Solid Phase Extraction, Strategies, and Application. NewYork.
[13] Abou El-Reasha, Y.G. (2016). Magnetic chitosan modified with cysteine-glutaraldehyde as adsorbent for removal of heavy metals from water. J Environ Chem Eng, 4, 3835-3847.
[14] Ozdemir, S., Turkan, Z., Kilinc, E., Bayat, R., Soylak, M., Sen, F. (2022). Selective detection of manganese (II) ions based on the fluorescence turn-on response via histidine functionalized carbon quantum dots. Environ Res 279, 112766- 121409.
[15] Farasati, M., Boroomandnasab, S., Abedi Koupai, J., Jafarzadeh, N., Moazed,H., Saiedian, M. (2012). Nitrate contaminated water treatment using micro and nanostructured sugarcane straw. JWSS. 16, 83-95.
[16] Hua, M., Zhang, Sh., Pan, B., Zhang, W., Zhang, Q. (2012). Heavy metal removal form water/wastewater by Nano-sized metal oxides. J Hazard Mater, 211, 317-331.
[17] Bahmaie, M., Abbasi, L., Faraji, M. (1392). Synthesis of magnetic nanoparticles (Fe3O4) and its application for extraction and preconcentration of drug sample from environmental samples Authors. JAC. 8, 29-37. (in Persian) 
[18] Abniki, M., Moghimi, A. (1400). Removal and measurement of bromocresol purple dye in aqueous samples by β-cyclodextrin-modified magnetic carbon nanotube with dispersive solid-phase extraction technique. JCST, 15,301-315. (in Persian) 
[19] Kayani, Z. N., Butt, M., Ali, Y., Riaz, S., Naseem, S. (2015). Structural and optical study of NiO nano-particles. Materials. Today. Proceedings. 2, 5804-5807.
[20] Park, Y. J., Fray, D. J. (2009). , Recovery of high purity precious metals from printed circuit boards. J. Hazard. Mater. J Hazard Mater. 164, 1152-1158.
[21] Pan, L., deZhang, Z. (2009). Solvent extraction and separation of palladium (II) and platinum(IV) from hydrochloric acid medium with dibutyl sulfoxide MineralsEng. MineralsEng, 1271-1276.
[22] Salehi, N., Moghimi, A. (1401). Synthesis of crosslinked magnetic chitosan to removal of trace amounts of some heavy metals from aqueous solutions. JCST, 2,135-145. (in Persian) 
[23] Alsalme, A., Ahmad, H., Khan, R. A., Koo, B. H., Alharbi, G. M., Alhadlaq, S. I. (2023). Preconcentration and solid phase extraction of trace metal ions by chemically modified graphene oxide nanoconstructs. water, 15(6),1121.
[24] Manzoori, J., Abdolmohammad-Zadeh, L., Amjadi, M. H. (2007). Ultra-trace determination of silver in water samples by electrothermal atomic absorption spectrometry after preconcentration with a ligand-less cloud point extraction methodology. J Hazard Mater, 144,458-463.
[25] Salehi, N., Moghimi, A., Shahbazi, H. (2022). Preparation of cross-linked magnetic chitosan with methionine-glutaraldehyde for removal of heavy metals from aqueous solutions.  Int J Environ Anal Chem, 102, 2305-2321.
[26] Abniki, M., Moghimi, A. (2021). Synthesis of chitosan functionalized magnetic carbon nanotubes for dispersive solid-phase extraction of bromocresol green. IET Nanobiotechnology 16(9), 455-469.
[27] Salehi, N., Moghimi, A., Shahbazi, H. (2021). Magnetic nano biosorbent (MG-Chi/Fe3O4) for dispersive solid phase extraction of Cu (II), Pb(II) and Cd(II) followed by FAAS determination. IET. Nanobiotechnology, 15, 575-584.
[28] Helzlsouer, K.J., Huang, H.Y., Alberg, A.J., Hoffman, S., Burke, A., Norkus, E.P., Morris, J.S., Comstock, G.W. (2000). Association between alpha-tocopherol, gamma-tocopherol, selenium and subsequent prost te cancer. J Natl Cancer I, 92, 2018-2023.
[29] Arvand, M.P., Moghimi, A., Abniki, M. (2022). A novel removal of Ni2+ ions from water solutions using dispersive solid-phase extraction method with nano Fe3O4/chitosan-acrylamide hydrogel. IET Nanobiotechnology.
[30] Abdolmohammad-Zadeh, H., Talleb, Z. (2015). Magnetic solid phase extraction of gemfibrozil from human serum and pharmaceutical wastewater samples utilizing a β-cyclodextrin grafted graphene oxide-magnetite nano-hybrid. Talanta, 134, 387-393.
[31] Patel, A. I., Prajapati, K. B., Jolapara, S. H., Vyas, A. J., Patel, A. B., Patel, N. K., Pandey, M. M. (2021). Rp-hplc method for determination of gemfibrozil using central composite design (CCD). Res J Pharm Technol, 14, 3009-3014.
[32] Villar, A. M. S., Campmany, A. C. C., Bellowa, L. H., Trenchs,  M. A., Naveros, B. C. (2013). Validated spectrofluorometric method for determination of gemfibrozil in self nanoemulsifying drug delivery systems (SNEDDS). Spectrochim. Acta A Mol, 113, 7-22.
Applied Chemistry Today
Volume 18, Issue 68
September 2023
Pages 323-342

Files

Share

How to cite

Statistics