Synthesis and characterization of mononuclear oxime palladacycles based phosphorus ligands, and evaluation of their catalytic and cytotoxicity activities

Articles in Press

Document Type : Original Article

Authors

1 Department of Chemistry, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran

2 Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran

Abstract

In the present investigation, a new series of mononuclear oxime palladacycles based on phosphorus ylides with the empirical formula [Pd{N,N'-C5H4{C(H)=NO}-2}(Ph2PCH2PPh2C(H)C(O)C6H4X)]ClO4 (X = Cl (1), Br (2), NO2(3) and OCH3 (4)) were synthesized. These complexes were formed through a cleavage chloro-bridges reaction of the dinuclear palladacycle complex in the presence of phosphorous ligands using sodium perchlorate and dichloromethane solvent. The synthesized complexes were characterized by elemental analysis, 31P NMR, 1H NMR, 13C NMR, and FT-IR spectroscopic methods. The obtained results of NMR and IR spectroscopes confirmed the synthesis of new mononuclear palladacycle complexes and the P,C-coordination mode connection for asymmetric phosphorus ylides. In addition, the catalytic activity of the synthesized complexes in the carbon-carbon coupling reaction and cytotoxic effect on A549, HT-29, and 1321N1 cell lines using the MTT-assay method. The results of this research can be promising for the use of these compounds as catalysts in the Suzuki–Miyaura carbon-carbon coupling reaction and anticancer agents.

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Applied Chemistry Today

Articles in Press, Accepted Manuscript
Available Online from 19 June 2024

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