Document Type : Original Article
Authors
1
Department of Applied Chemistry, Faculty of Chemistry, Razi University, Kermanshah, Iran
2
Department of Applied Chemistry, Faculty of Chemistry, Razi University, Kermanshah, Iran. Nanobiotechnology Department, Faculty of Innovative Science and Technology, Razi University, Kermanshah, Iran
3
Department of Applied Chemistry, Faculty of Chemistry, Razi University, Kermanshah, Iran. Environmental Research Center (ERC), Razi University, Kermanshah, Iran
4
Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran. USERN Office, Kermanshah University of Medical Sciences, Kermanshah, Iran
Abstract
A novel drug delivery system using an asymmetric polyethersulfone-based membrane modified with SBA-15 was developed in this study and aimed at enhancing azithromycin transdermal delivery. The research focused on optimizing membrane performance by adjusting key parameters, including drug concentration, membrane thickness, and modifier percentage. Various techniques were employed to characterize the performance of the fabricated membranes, including scanning electron microscopy, water contact angle measurements, hemocompatibility tests, and antibacterial assessments.
Following optimization, a membrane composition of 17% PES, 2% polyvinylpyrrolidone, and 1% SBA-15 was identified as the most effective. The optimized membranes substantially increased drug release compared to the unmodified membrane. The unique structure of the membrane, featuring a dense top layer that facilitates sustained drug release and a porous sub-layer that acts as a drug reservoir, significantly contributed to this improvement. Biocompatibility assessments, antibacterial activity analysis, and blood compatibility evaluations confirmed the promising biocompatibility of the optimized membranes. These evaluations demonstrated that the modified membranes are effective in enhancing drug delivery and safe for potential use in clinical applications.
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