MWCNTs modified carbon paste electrode for sensitive determination of antiparkinson drug entacapone in the bulk, pharmaceutical and human biological human samples

Document Type : Original Article


1 Department of Chemistry, Semnan University, Semnan , Iran

2 Department of Chemistry, Semnan University, Semnan 35195-363, Iran

3 Analytical chemistry, chemistry, Semnan university, Semnan, Iran


In this paper, the voltammetric properties of entacapone, an anti-Parkinson’s disease drug, were investigated by cyclic voltammetry and differential pulse voltammetry at MWCNTs modified carbon paste electrode in phosphate buffer in presence of Tween 20 and validated for quantitative determination of entacapone in bulk, pharmaceutical dosage forms and human plasma. Several factors such as pH, type of surfactant and scan rate were investigated in order to study the optimum conditions for determination of entacapone. A good linear relationship was obtained within the concentration range from 50 ˟ 10-9 to 2.4˟10-3M. The limits of detection and limit of quantification were found to be 8×10-10and 2.4×10-9molL-1, respectively. The proposed method was simple, rapid and economic, so it is suitable for routine analysis of entacapone in pure form and dosage forms and for pharmaco kinetic studies.


Main Subjects

[1] E. M. Ghoneim and H. S. El-Desoky, Journal of The Electrochemical Society163(2016) H89.
[2] J. Chen, B. K. Lipska, N. Halim, Q. D. Ma, M. Matsumoto, S. Melhem, B. S. Kolachana, T. M. Hyde, M. M. Herman and J. Apud, The American Journal of Human Genetics, 75(2004)807.
[3] S. Koradia, N. Jivani, S. Malaviya, S. Chauhan and S. Vaghani, International journal of Chromatographic science, 7(2009) 349.
[4] O. Paija, K. Laine, E.-R. Kultalahti, M. Leinonen, R. Huupponen, A. Gordin and K. Reinikainen, Clinical neuropharmacology, 28(2005)115.
[5] K. E. Lyons and R. Pahwa, Clinical neuropharmacology, 29(2006)73.
[6] D. Brooks, Y. Agid, K. Eggert, H. Widner, K. Østergaard and A. Holopainen, European neurology, 53(2005)197.
[7] K. J. Holm and C. M. Spencer, Drugs, 58(1999)159.
[8] J. Prous, X. Rabasseda and J. Castaner, Drugs of the Future, 19(1994) 641.
[9] M. Karlsson and T. Wikberg, Journal of pharmaceutical and biomedical analysis, 10(1992)593.
[10] C. S. Paim, M. T. Martins, M. D. Malesuik and M. Steppe, Journal of chromatographic science, 48(2010) 755.
[11] S. K. Shetty, K. Surendranath, P. Radhakrishnanand, J. Satish, J. Jogul and U. M. Tripathi, Chromatographia, 69(2009) 1189.
[12] F. Bugamelli, C. Marcheselli, E. Barba and M. Raggi, Journal of pharmaceutical and biomedical analysis, 54(2011) 562.
[13] Y. M. Issa, M. E. Hassoun and A. G. Zayed, Journal of Liquid Chromatography & Related Technologies, 34(2011) 2433.
[14] D. Gandhi and P. Mehta, JPC-Journal of Planar Chromatography-Modern TLC, 24(2011) 236.
[15] N. Soukhova, Z. Kassymbek, S. Bradby, A. Martin-Esker, P. White and S. Wahab, Journal of pharmaceutical and biomedical analysis, 54(2011) 860.
[16] R. K. Dhawan, R. Ravi, T. Subburaju, H. Revathi, C. Arul and N. G. Rao, International Journal of Pharmaceutical Sciences and Research, 4(2013) 1227.
[17] V. R. Krishna, K. B. M. Krishna and B. H. Babu, Journal of Pharmacy Research Vol, 8(2014)281.
[18] N. GADALLAH MOHAMED and M. SULTAN MOHAMED, Journal of the Chilean Chemical Society, 55(2010) 85.
[19] K. Rajeswari, G. Sankar, A. Rao and J. Rao, Int. J. of Chem. Sci, 4(2006) 694.
[20] C. Paim, H. Gonçalves, A. Lange, D. Miron and M. Steppe, Analytical Letters, 41(2008) 571.
[21] S. Chalikwar, A. Shirkhedkar, M. Bagul, P. Jain and S. Surana, Pharmaceutical Methods, 3(2012) 14.
[22] R. Balusani and S. Rao, World Journal of Pharmacy and Pharmaceutical Sciences, 4(2015) 1617.
[23] J. Shah, S. K. Banerjee and G. S. Chhabra, Bulletin of Pharmaceutical Research, 1(2011) 7.
[24] R. Jain, N. Jain, D. K. Jain and S. K. Jain, Advanced pharmaceutical bulletin, 3(2013) 409.
[25] S. K. Koradia, A. Agola, N. Jivani, R. Manek and S. Pandey, Int J Pharm Res Dev, 1(2009)1.
[26] H. Keski-Hynnilä, K. Raanaa, J. Taskinen and R. Kostiainen, Journal of Chromatography B: Biomedical Sciences and Applications, 749(2000) 253.
[27] M. L. Abasq, P. Courtel and G. Burgot, Analytical Letters, 41(2008)56.
[28] R. Jain, R. K. Yadav and A. Dwivedi, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 359(2010) 25.
[29] N. N. Salama, S. M. Azab, M. A. Mohamed and A. M. Fekry, RSC Advances, 5(2015)14187.
[30] M. Rizk, A. K. Attia, M. S. Elshahed and A. S. Farag, Journal of Electroanalytical Chemistry, 743(2015) 112.
[31] S. Iijima and T. Ichihashi, Nature, 363(1993) 603.
[32] A. T. Masheter, P. Abiman, G. G. Wildgoose, E. Wong, L. Xiao, N. V. Rees, R. Taylor, G. A. Attard, R. Baron and A. Crossley, Journal of Materials Chemistry, 17(2007)2616.
[33] R. Vittal, H. Gomathi and K.-J. Kim, Advances in colloid and interface science, 119(2006)55.
[34] N. F. Atta and H. Ekram, Nanosensors: Materials and Technologies,( 2014) 143.
[35] N. F. Atta, E. H. El-Ads and A. Galal, Handbook of Nanoelectrochemistry: Electrochemical Synthesis Methods, Properties, and Characterization Techniques, (2016)417.
[36] J. C. Abbar and S. T. Nandibewoor, Colloids and Surfaces B: Biointerfaces, 106(2013) 158.
[37] A. Levent, A. Altun, Y. Yardım and Z. Şentürk, Electrochimica Acta, 128(2014)54.
[38] J. M. You and S. Jeon, Electroanalysis, 23(2011) 2103.
[39] A.Benvidi , MT .Nafar , S.Jahanbani , MD .Tezerjani, M. Rezaeinasab , S.Dalirnasab . Mater Sci Eng C Mater Biol Appl, (2017) 75 1435.
[40] A. Benvidi, Pa.Kakoolaki, H.Zare, ,ElectrochimicaActa, 56 (2011) Pages 1925.