Synthesis of bis-chalcones based on 5, 5΄-methylene bis(2-hydroxybenzaldehyde) and screening their antibacterial activity


A one-pot synthesis of novel derivatives of bis-chalcones by condensation of prepared bis-aldehyde and different ketones in basic media have been described. Compounds were characterized by IR, 1H NMR, 13C NMR and EI-Mass spectra. The antibacterial activities of bis-chalcones were evaluated against Staphylococcus Aureus, Escherichia coli, Pseudomonas aeruginosa and Bacillus subtilis. Biological data indicated that some products exhibit promising activities. A significant reasonable reaction time, a nearly quantitative yield, and high atom economy in the product were observed. The simplicity of the reaction, ease of execution, simple workup, and good yields, with the use of easily accessible starting materials is hallmarks of this process.