نوع مقاله : مقاله علمی پژوهشی
نویسندگان
گروه شیمی، دانشکده علوم پایه، دانشگاه شهرکرد، شهرکرد، ایران
چکیده
کلیدواژهها
موضوعات
عنوان مقاله [English]
نویسندگان [English]
In this study, a simple and efficient method for the synthesis of various amines via the reductive amination of carbonyl compounds has been developed. The reaction was carried out at room temperature using anilines, aldehydes, or ketones, with tartaric acid as a green, inexpensive, and non-toxic catalyst, in the presence of sodium borohydride (NaBH₄) as the reducing agent. Tartaric acid plays a key role both in the formation of the imine intermediate and in facilitating its reduction to the corresponding amine. This method exhibits high yields and tolerates a wide range of substrates, including aromatic and aliphatic amines, as well as various aldehydes and ketones. The synthesized amines were characterized using FTIR and ¹H NMR spectroscopy. The approach offers several advantages, such as high efficiency, mild reaction conditions, avoidance of hazardous reagents, and minimized by-product formation. The findings of this study highlight tartaric acid as an effective and sustainable catalyst for reductive amination under mild conditions.
کلیدواژهها [English]
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