نوع مقاله : مقاله علمی پژوهشی
نویسندگان
گروه شیمی معدنی، دانشکده شیمی، دانشگاه دامغان، دامغان، ایران
چکیده
کلیدواژهها
موضوعات
عنوان مقاله [English]
نویسندگان [English]
Platinum(IV) containing 2-mercaptobenzothiazole disulfide (MBTS) ligand with a disulfide bond was synthesized through the reaction of [PtAr2(SMe2)2] (Ar = Ph) with 2-mercaptobenzothiazole disulfide. Also, the complex containing Ar = p-tolyl groups was synthesized and their biochemical properties were compared. In this research, 2-mercaptobenzothiazole (MBT) was constructed during the breaking of the S–S bond in 2-mercaptobenzothiazole disulfide (MBTS), which then act as a sulfur-nitrogen chelating ligand. The synthesized organometallic compounds were identified using various spectroscopy methods such as FT-IR, 1HNMR, elemental analysis, and electronic spectra. Furthermore, the interactions of synthesized compounds and DNA (deoxyribonucleic acid) were studied using different techniques such as electronic and photoluminescence spectroscopy and viscosity investigations. The intrinsic binding constants containing Kb and Kf were calculated for Pt complexes at different temperatures, and the obtained data were compared with each other. The spectra of emission and absorption changed upon the addition of DNA. Moreover, thermodynamic parameters of the interaction between Pt compounds and deoxyribonucleic acid were obtained. The resulting Kb values confirmed the Pt complexes considerably interacted with DNA. The obtained positive changes in enthalpy and entropy confirmed the corresponding hydrophobic interaction. The viscosity of deoxyribonucleic acid was increased during the addition of complexes, indicating the interaction with these compounds. The obtained data indicated the mechanism of intercalative for CT-DNA interactions with Pt complexes. Moreover, comparing the intrinsic binding constants data showed that the interaction of the organoplatinum complex containing phenyl groups with DNA is more than its analogue containing para-tolyl groups.
کلیدواژهها [English]
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