شیمى کاربردى روز

شیمى کاربردى روز

اندازه گیری الگتروشیمیایی داروی ضدسرطان اپی روبیسین در نمونه های آمپول و سرم با استفاده الکترود خمیرکربن اصلاح شده با نانوکامپوزیت اکسیدنیکل/نانولوله کربنی

نوع مقاله : مقاله علمی پژوهشی

نویسندگان
1 دانشکده شیمی، گروه شیمی تجزیه، دانشگاه دامغان، دامغان، ایران
2 دانشکده علوم محیطی، دانشگاه علوم و الکترونیک چین، چنگدو، چین
10.22075/chem.2026.36848.2343
چکیده
در این کار تحقیقاتی، نانوکامپوزیت اکسید نیکل/نانولوله کربنی با استفاده از روش رسوب دهی مستقیم سنتز و با استفاده از روش میکروسکوپ الکترونی عبوری و آنالیز عنصری مورد شناسایی قرار گرفت. سپس، الکترود خمیرکربن اصلاح شده با نانوکامپوزیت اکسید نیکل/نانولوله کربنی با درصد وزنی بهینه (10% وزنی-وزنی) تهیه و سنسور طراحی شده برای بررسی الکتروشیمیایی رفتار اپی روبیسین بکار گرفته شد. نتایج نشان می دهد که بیشترین حساسیت در شرایط خنثی حاصل شده است. سنسور طراحی شده بخوبی اپی روبیسین را در محدوده غلظتی 320- 0.01 میکرومولار شناسایی و حدتشخیص 8 نانومولار برای اندازه گیری آن در سطح سنسور گزارش نموده است. سنسور اصلاح شده توانایی کاتالیزوری مناسبی در افزایش جریان اکسیداسیون و همچنین کاهش اضافه ولتاژ دارو را نشان داده است. در نهایت، سنسور پیشنهادی برای اندازه گیری اپی روبیسین در نمونه های امپول و سرم قندی استفاده شده و نتایج درصد بازیابی 97.4 –102.8% نشان داده است که برای یک سنسور جدید قابل قبول می باشد.
کلیدواژه‌ها
موضوعات

عنوان مقاله English

Electrochemical measurement of the anticancer drug epirubicin in injection and serum samples using a carbon paste electrode modified with NiO/carbon nanotube nanocomposite

نویسندگان English

Hassan Karimi-Maleh 1
Najmeh Zare 2
1 School of Chemistry, Damghan University, Damghan 36716-45667, Iran
2 School of Resources and Environment, University of Electronic Science and Technology of China, Chengdu, China
چکیده English

In this research work, NiO/carbon nanotube nanocomposite (NiO/CNTs) was synthesized using direct deposition method and characterized using Transmission electron microscopy (TEM) and elemental analysis (EDS). Then, carbon paste electrode modified with NiO/CNTs nanocomposite with optimal weight percentage (10% w/w) was prepared and the designed sensor was used to investigate the electrochemical behavior of epirubicin. The results showed that the highest sensitivity was achieved under neutral conditions. The designed sensor detected epirubicin well in the concentration range of 0.01-320 μM and a detection limit of 8 nM was obtained for the measurement of epirubicin on the surface of the new sensor. The modified sensor has shown good catalytic ability in increasing the oxidation current as well as reducing the drug overvoltage. Finally, the proposed sensor was used to measure epirubicin in injection and dextrose saline samples and the results showed a recovery percentage of 97.4%-102.8%, which is acceptable for a new sensor.

کلیدواژه‌ها English

Epirubicin
Modified Electrode
NiO/CNTs nanocomposite
Sensor
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