استفاده از آزمایش طراحی RSM برای تهیه نانو ذرات حاوی پیرازینامید، اتامبوتول و ریفامپین

نوع مقاله: مقاله علمی پژوهشی

نویسندگان

1 ایران، تهران، دانشگاه آزاد اسلامی واحد تهران شمال، گروه شیمی

2 ایران، سمنان، دانشگاه سمنان، دانشکده دامپزشکی، بخش بیوشیمی

چکیده

در این تحقیق، نانوذرات سه جزئی آهن، نیکل و لیتیوم با دو روش ترکیبی (هم رسوبی، هیدروترمال) و پچینی سل-ژل سنتز شدند. شرایط مطلوب برای تولید MNPs با استفاده از روش هم رسوبی در pH=13 با 1000 دور در دقیقه و در دمای 72 درجه سانتیگراد در محدوده ی نیتروژن به دست آمد. بهترین شرایط برای تهیه نانو ذرات با استفاده از روش پچینی سل-ژل شامل حل نمک های نیترات سه فلز در آب و سپس اضافه کردن اسید سیتریک و اتیلن گلیکول به ترتیب در دماهای 60 و 80 با کنترل pH = 7 و قرار دادن نمونه ها در دمای 190 و 500 برای 720 و 60 دقیقه بدست آمد. در مقایسه دو روش، مورفولوژی و اندازه نانو ذرات مغناطیسی تولید شده با روش ترکیبی هم رسوبی - هیدروترمال مناسب تر بود. برای بررسی بهترین نانوذرات سنتز شده از روش بررسی سطوح پاسخ (RSM) در اندازه گیری استفاده شد. گروه های سیلیس و آمین در نانوذرات پوشش داده شد.

کلیدواژه‌ها

موضوعات


عنوان مقاله [English]

Using the design experiment RSM for the preparation of nanoparticles containing pyrazinamide, ethambutol and rifampin

نویسندگان [English]

  • Fariba Tadayon 1
  • reza jamshidi 2
  • parisa Jamshidpour 1
1 Department of Chemistry, North Tehran Branch, Islamic Azad University, Tehran, Iran
2 department of biochemistry, faculty of veterinary, semnan university, Semnan, Iran
چکیده [English]

In this study, three-component nanoparticles of iron, nickel and lithium were synthesized with two methods of combined technique (co-precipitation, hydrothermal) and pechini sol-gel. The optimum conditions for producing magnetic nanoparticles (MNPs) by co-precipitation method were found to be at pH=13 with constant stirring rate of 1000 rpm and at temperature of 72 ˚C under nitrogen atmosphere. The situation for preparing nanoparticles by pechini sol-gel method including dissolving nitrate salt of three metals in water then adding citric acid and ethylene glycol respectively in temperatures 60 and 80 0 C with pH=7 and placing sample in temperatures 190 and 500 0 C for 720 and 60 minutes respectively. In the comparison of two methods, morphology and size of produced magnetic nanoparticles with combined method of co-precipitation- hydrothermal was more suitable. Response surface methodology was used to verify the best synthesized nanoparticles in size. The surface of MNPs was modified with silica and amine groups to develop a suitable drug delivery system.

کلیدواژه‌ها [English]

  • magnetic nanoparticles
  • Response surface methodology
  • Pechini sol-gel
  • Hydrothermal
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