1 1گروه شیمی آلی، دانشکده شیمی٬ دانشگاه بوعلی سینا همدان٬ ایران
2 2 گروه شیمی٬ دانشگاه پیام نور٬ تهران٬ ایران
عنوان مقاله [English]
Controlled drug release is one of the most important methods to increase the therapeutic effects and decrease side effects of drug. In this research, three drugs (piperazine, 8-aminoquinoline, N-phenyl piperazine) were attached chemically to the p-styrene sulphonyl chloride (as monomer), and they were polymerized by AIBN ( Azobis isobutyro nitrile) at 80 Â°C. Finally, release ability of three polymer-drugs were tested in buffer solution with pH= 1.3 at the temperature 37 Â°C. The GPC spectra of the polymers showed that polymerization of monomers containing drugs were carried out. The results established that, these polymeric systems are able to release drugs.