استخراج فاز جامد بر پایه نانوکامپوزیت‌ گرافن اکسیدمغناطیسی و طیف‌سنجی تحرک یونی در تعیین بوپروپیون

نوع مقاله : مقاله علمی پژوهشی

نویسندگان

گروه شیمی، دانشگاه آزاد اسلامی یزد، یزد، ایران

چکیده

در این مقاله استخراج کمی داروی بوپروپیون با روش استخراج فاز جامد بر پایه نانوکامپوزیت گرافن‌اکسید مغناطیسی معرفی شده است. مشخصه‌یابی و مطالعات ساختاری جاذب سنتز شده با استفاده از تکنیک‌های طیف‌سنجی زیرقرمز تبدیل فوریه، میکروسکوپ الکترونی روبشی و پراش اشعه ایکس انجام شد. بوپروپیون با طیف‌سنجی تحرک یونی به‌عنوان یک روش حساس، سریع و ساده تعیین مقدار شد. پارامترهای تجربی مؤثر بر بازده استخراج روش پیشنهادی شامل حلال واجذبی (نوع و حجم)، میزان جاذب، pH، دمای استخراج، زمان استخراج و حجم محلول اولیه بررسی و بهینه شدند. در شرایط بهینه، منحنی-های‌ درجه‌بندی در دو گستره 10-4 و ng 24-10 با ضرایب تعیین 98/0R2≥ خطی بودند. انحراف استاندارد نسبی 5% و همچنین مقادیر حدتشخیص و حدتعیین به ترتیب 66/0 و ng 20/2 گزارش شدند. کاربرد روش پیشنهادی در نمونه‌های مختلف قرص با دوزهای متفاوت از بوپروپیون ارزیابی شد که نتایج کمی رضایت بخشی را به‌دنبال داشت (درصد بازیابی: 0/92-0/88).

کلیدواژه‌ها

موضوعات


عنوان مقاله [English]

Solid phase extraction based on magnetic graphene oxide nanocomposite and ion mobility spectrometry for determination of bupropion

نویسندگان [English]

  • Farideh Shamsi
  • Ali Sheibani
  • M. Reza Shishebore
Department of Chemistry, Yazd Branch, Islamic Azad University, Yazd, Iran
چکیده [English]

In this paper, a solid phase extraction based on magnetic graphene oxide nanocomposite has been introduced for the quantitative extraction of bupropion. The characterization and structural studies for the nanocomposite were carried out by fourier transform infrared spectrometry, scanning electron microscopy and X–ray diffraction techniques. Ion mobility spectrometry as a sensitive, rapid and simple method was applied for the determination of bupropion. The effect of experimental parameters (including desorption solvent: type and volume, adsorbent amount, pH, temperature and time extraction, and initial solution volume) on the extraction efficiency of the proposed method was investigated. Under optimum conditions, the calibration curves were linear in the two ranges of 4–10 and 10–24 ng with coefficients of determination R2≥ 0.98. The relative standard deviation was 5% and also the limits of detection and quantification were 0.66 and 2.20 ng, respectively. The proposed method was applied for the different brand tablets with various doses of bupropion which the satisfactory quantitative results were obtained (recovery: 88.0–92.0%).

کلیدواژه‌ها [English]

  • Bupropion
  • Magnetic solid phase extraction
  • Magnetic graphene oxide nanocomposite
  • Ion mobility spectrometry

This is an open access article under the CC-BY-SA 4.0 license.( https://creativecommons.org/licenses/by-sa/4.0/)

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