Chemiluminescence determination of pethidine hydrochloride and thebaine alkaloides

Document Type : Original Article

Authors

Department of Chemistry, Faculty of Basic Sciences, Golestan University, Gorgan, Iran

Abstract

The aim of this work was finding new flurescent dyes as sensitizers for chemiluminescence (CL) determination some of narcotics. In this way 6 different dyes incloding rhodamine 6G, brilliant blue, orange G, chromatrope, eosin‌‌Y and [Ru(phen)3]2+ and 14 drugs incloding pethidine hydrochloride, thebaine, dextromethorphan, acetaminophen, codeine, oxymorphone, oxycodone, morphine, pholcodine, naltrexone, buprenorphine, methadone, tramadol, diphenoxylate were investigated. In the preliminary experiments, we found that pethidine hydrochloride in CL system of [Ru(phen)3]2+- Ce(IV) and thebaine in CL system of rhodamine 6G- Ce(IV) could be determined. After optimizing the important variables, linear dynamic range for pethidine hydrochloride and thebaine were 5.6×10-7 to 1.4×10-3 mol L-1 and 1.0×10-5 to 4.0×10-4 mol L-1 and limit of detection were 7.1×10-8 mol L-1 and 4.3×10-6 mol L-1, respectively. The percent of relative standard deviation for pethidine hydrochloride and thebaine were 5.7 and 4.0%, respectively.

Keywords

Main Subjects

This is an open access article under the CC-BY-SA 4.0 license.( https://creativecommons.org/licenses/by-sa/4.0/)

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Applied Chemistry Today
Volume 18, Issue 68
September 2023
Pages 83-106

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