تعیین مقدار آلکالوئیدهای پتیدین هیدروکلراید و تبائین به روش نورتابی شیمیایی

نوع مقاله : مقاله علمی پژوهشی

نویسندگان

گروه شیمی، دانشکده علوم پایه، دانشگاه گلستان، گرگان، ایران

چکیده

هدف از این تحقیق بررسی چند نمونه رنگ فلوئورسانس‌کننده به عنوان حساس کننده در تعیین مقدار مواد مخدر به روش نورتابی ‌شیمیایی است. برای این منظور تعداد 6 رنگ مختلف شامل رُدامین 6G، برلینت بلو، اورنج G، کروماتروپ، ائوسین‌Y و دی کلرو تریس(1و10-فنانترولین) روتنیوم(II) هیدرات ([Ru(phen)3]2+) و تعداد 14 ماده مخدر و ضد درد شامل پتیدین هیدروکلراید، تبائین، دکسترومتورفان، استامینوفن، کدئین، اکسی‌مورفون، اکسی‌کدون، مورفین، فولکدین، نالترکسون، بوپرنورفین، متادون، ترامادول و دیفنوکسیلات مورد بررسی قرار گرفتند. در بررسی‌های اولیه مشخص شد ترکیب پتیدین هیدروکلراید در سیستم نورتابی ‌شیمیایی [Ru(phen)3]2+-Cerium(IV) و ترکیب تبائین در سیستم نورتابی ‌شیمیایی رُدامین 6G Cerium(IV)- قابل تعیین هستند. پس از بهینه سازی متغیرهای تاثیر گذار، ناحیه خطی و حد تشخیص برای پتیدین هیدروکلراید به ترتیب 7˗١٠×6/5 تا 3˗١٠×4/1 و 8˗١٠×1/7 مولار و برای تبائین 5˗١٠×1 تا 4˗١٠×4 و 6˗١٠×3/4 مولار محاسبه شد. درصد انحراف نسبی برای پتیدین هیدروکلراید و تبائین به ترتیب 7/5 و 0/4 درصد بدست آمد.

کلیدواژه‌ها

موضوعات


عنوان مقاله [English]

Chemiluminescence determination of pethidine hydrochloride and thebaine alkaloides

نویسندگان [English]

  • Massoud Karimi
  • Ali Mokhtari
  • Aliakbar Dehno Khalaji
Department of Chemistry, Faculty of Basic Sciences, Golestan University, Gorgan, Iran
چکیده [English]

The aim of this work was finding new flurescent dyes as sensitizers for chemiluminescence (CL) determination some of narcotics. In this way 6 different dyes incloding rhodamine 6G, brilliant blue, orange G, chromatrope, eosin‌‌Y and [Ru(phen)3]2+ and 14 drugs incloding pethidine hydrochloride, thebaine, dextromethorphan, acetaminophen, codeine, oxymorphone, oxycodone, morphine, pholcodine, naltrexone, buprenorphine, methadone, tramadol, diphenoxylate were investigated. In the preliminary experiments, we found that pethidine hydrochloride in CL system of [Ru(phen)3]2+- Ce(IV) and thebaine in CL system of rhodamine 6G- Ce(IV) could be determined. After optimizing the important variables, linear dynamic range for pethidine hydrochloride and thebaine were 5.6×10-7 to 1.4×10-3 mol L-1 and 1.0×10-5 to 4.0×10-4 mol L-1 and limit of detection were 7.1×10-8 mol L-1 and 4.3×10-6 mol L-1, respectively. The percent of relative standard deviation for pethidine hydrochloride and thebaine were 5.7 and 4.0%, respectively.

کلیدواژه‌ها [English]

  • Chemiluminescence
  • Sensitizer
  • Rhodamine 6G
  • [Ru(phen)3]2+
  • pethidine hysrochloride
  • thebaine

This is an open access article under the CC-BY-SA 4.0 license.( https://creativecommons.org/licenses/by-sa/4.0/)

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