شیمى کاربردى روز

شیمى کاربردى روز

ساخت یک پچ ترانس‌درمال پلیمری جدید اصلاح‌شده با فیلر مزوپور

نوع مقاله : مقاله علمی پژوهشی

نویسندگان
1 گروه شیمی کاربردی، دانشکده شیمی، دانشگاه رازی، کرمانشاه، ایران
2 گروه شیمی کاربردی، دانشکده شیمی، دانشگاه رازی، کرمانشاه، ایران. گروه نانوبیوتکنولوژی، دانشکده علوم و فناوری نوآورانه، دانشگاه رازی، کرمانشاه، ایران
3 گروه شیمی کاربردی، دانشکده شیمی، دانشگاه رازی، کرمانشاه، ایران. مرکز تحقیقات محیطی (ERC)، دانشگاه رازی، کرمانشاه، ایران
4 مرکز تحقیقات علوم دارویی، پژوهشکده بهداشت، دانشگاه علوم پزشکی کرمانشاه، کرمانشاه، ایران. دفتر USERN، دانشگاه علوم پزشکی کرمانشاه، کرمانشاه، ایران
چکیده
این مطالعه یک سیستم پیشرفته انتقال دارو را توسعه داد که شامل غشای نامتقارن مبتنی بر PES تقویت‌شده با SBA-15 اصلاح‌شده برای بهبود انتقال ترانس‌درمال آزیترومایسین است. هدف این پژوهش، بهینه‌سازی عملکرد غشا از طریق تنظیم پارامترهای کلیدی نظیر غلظت دارو، ضخامت غشا و درصد اصلاح‌کننده بود. برای ارزیابی عملکرد غشاهای ساخته‌شده، از تکنیک‌های متعددی شامل میکروسکوپ الکترونی روبشی، اندازه‌گیری زاویه تماس آب، آزمایش‌های خون سازگاری و ارزیابی‌های ضدباکتریایی استفاده شد.
پس از بهینه‌سازی، ترکیب غشایی شامل ۱۷٪ PES، ۲٪ پلی‌وینیل‌پیرولیدون (PVP)، و ۱٪ SBA-15 اصلاح‌شده به‌عنوان مؤثرترین ترکیب شناسایی شد. غشاهای بهینه‌شده آزادسازی دارو را به‌طور قابل‌توجهی نسبت به غشاهای اصلاح‌نشده بهبود دادند. این بهبود به ساختار منحصربه‌فرد غشا نسبت داده شد که شامل یک لایه بالایی متراکم برای آزادسازی پایدار دارو و یک زیرلایه متخلخل به‌عنوان مخزن دارو است. آزمایش‌های زیست‌سازگاری، تحلیل فعالیت ضدباکتریایی و ارزیابی سازگاری خونی نشان دادند که غشاهای بهینه‌شده زیست‌سازگار هستند. یافته‌ها نشان دادند که غشاهای اصلاح‌شده در بهبود انتقال دارو مؤثر بوده و برای کاربردهای بالینی بالقوه ایمن هستند.
کلیدواژه‌ها
موضوعات

عنوان مقاله English

Fabrication of new polymeric transdermal patch modified by mesoporous filler

نویسندگان English

Mahya Samari 1
Soheila Kashanian 2
Sirus Zinadini 3
Hossein Derakhshankhah 4
1 Department of Applied Chemistry, Faculty of Chemistry, Razi University, Kermanshah, Iran
2 Department of Applied Chemistry, Faculty of Chemistry, Razi University, Kermanshah, Iran. Nanobiotechnology Department, Faculty of Innovative Science and Technology, Razi University, Kermanshah, Iran
3 Department of Applied Chemistry, Faculty of Chemistry, Razi University, Kermanshah, Iran. Environmental Research Center (ERC), Razi University, Kermanshah, Iran
4 Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran. USERN Office, Kermanshah University of Medical Sciences, Kermanshah, Iran
چکیده English

A novel drug delivery system using an asymmetric polyethersulfone-based membrane modified with SBA-15 was developed in this study and aimed at enhancing azithromycin transdermal delivery. The research focused on optimizing membrane performance by adjusting key parameters, including drug concentration, membrane thickness, and modifier percentage. Various techniques were employed to characterize the performance of the fabricated membranes, including scanning electron microscopy, water contact angle measurements, hemocompatibility tests, and antibacterial assessments.
Following optimization, a membrane composition of 17% PES, 2% polyvinylpyrrolidone, and 1% SBA-15 was identified as the most effective. The optimized membranes substantially increased drug release compared to the unmodified membrane. The unique structure of the membrane, featuring a dense top layer that facilitates sustained drug release and a porous sub-layer that acts as a drug reservoir, significantly contributed to this improvement. Biocompatibility assessments, antibacterial activity analysis, and blood compatibility evaluations confirmed the promising biocompatibility of the optimized membranes. These evaluations demonstrated that the modified membranes are effective in enhancing drug delivery and safe for potential use in clinical applications.

کلیدواژه‌ها English

Transdermal drug delivery
mesoporous filler
polymeric membrane
azithromycin
[1] Teschke, R., Sarris, J., & Schweitzer, I. (2012). Kava hepatotoxicity in traditional and modern use: the presumed Pacific kava paradox hypothesis revisited. British journal of clinical pharmacology73(2), 170-174.
[2] Rombey, T., Puljak, L., Allers, K., Ruano, J., & Pieper, D. (2020). Inconsistent views among systematic review authors toward publishing protocols as peer-reviewed articles: an international survey. Journal of clinical epidemiology123, 9-17.
[3] Cheng, H. Y., Jian, S. W., Liu, D. P., Ng, T. C., Huang, W. T., & Lin, H. H. (2020). Contact tracing assessment of COVID-19 transmission dynamics in Taiwan and risk at different exposure periods before and after symptom onset. JAMA internal medicine180(9), 1156-1163.
[4] Cutler, W., Kolter, J., Chambliss, C., O’Neill, H., & Montesinos-Yufa, H. M. (2020). Long term absence of invasive breast cancer diagnosis in 2,402,672 pre and postmenopausal women: A systematic review and meta-analysis. Plos one, 15(9), e0237925.
[5] IM, S. (2000). Association of glycemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ, 321, 405012.
[6] Chan, K. H., Yan, M., Bennett, D. A., Guo, Y., Chen, Y., Yang, L., ... & China Kadoorie Biobank Study group. (2021). Long-term solid fuel use and risks of major eye diseases in China: A population-based cohort study of 486,532 adults. PLoS medicine18(7), e1003716.
[7] Gilhofer, T. S., & Saw, J. (2019). Spontaneous coronary artery dissection: update 2019. Current Opinion in Cardiology34(6), 594-602.
[8] Jeong, H. M., Weon, K. Y., Shin, B. S., & Shin, S. (2020). 3D-printed gastroretentive sustained release drug delivery system by applying design of experiment approach. Molecules, 25(10), 2330.
[9] Aithal, G. P., Watkins, P. B., Andrade, R. J., Larrey, D., Molokhia, M., Takikawa, H., ... & Daly, A. K. (2011). Case definition and phenotype standardization in druginduced liver injury. Clinical Pharmacology & Therapeutics89(6), 806-815.
[10] Peppi, M., Marie, A., Belline, C., & Borenstein, J. T. (2018). Intracochlear drug delivery systems: a novel approach whose time has come. Expert Opinion on Drug Delivery15(4), 319-324.
[11] Israel, D. A., Salama, N., Arnold, C. N., Moss, S. F., Ando, T., Wirth, H. P. & Peek, R. M. (2001). Helicobacter pylori strain-specific differences in genetic content, identified by microarray, influence host inflammatory responses. The Journal of clinical investigation107(5), 611-620.
[12] Svensson, C. K. (1987). Clinical pharmacokinetics of nicotine. Clinical pharmacokinetics12, 30-40.
[13] Stillhart, C., Vučićević, K., Augustijns, P., Basit, A. W., Batchelor, H., Flanagan, T. R. & Müllertz, A. (2020). Impact of gastrointestinal physiology on drug absorption in special populations––An UNGAP review. European Journal of Pharmaceutical Sciences147, 105280.
[14] Prandota, J. (1982). Urinary elimination kinetics and diuretic effect of intravenous furosemide in nephrotic children. Developmental Pharmacology and Therapeutics5(1-2), 98-108.
[15] Sánchez-Zapardiel, E., Mancebo, E., Díaz-Ordoñez, M., de Jorge-Huerta, L., Ruiz-Martínez, L., Serrano, A. & Paz-Artal, E. (2016). Isolated de novo antiendothelial cell antibodies and kidney transplant rejection. American Journal of Kidney Diseases68(6), 933-943.
[16] JE, V. R., Sharpe, L. A., & Peppas, N. A. (2018). Corrigendum to'Current state and challenges in developing oral vaccines'[Adv. Drug Deliv. Rev. 114 (2017) 116-131]. Advanced Drug Delivery Reviews139, 158-158.
[17] Petersen, C. (2018). Christine Petersen: Pioneering Leishmania Research in Man and Man's Best Friend. TRENDS IN PARASITOLOGY34(7), 543-544.
[18] DiMatteo, M. R., Giordani, P. J., Lepper, H. S., & Croghan, T. W. (2002). Patient adherence and medical treatment outcomes: a meta-analysis. Medical care40(9), 794-811.
[19] Osterberg, L., & Blaschke, T. (2005). Adherence to medication. New England journal of medicine353(5), 487-497.
[20] Chen, J., Wang, J., Lu, Y., Zhao, S., Yu, Q., Wang, X. & Jiang, Y. (2018). Uncovering potential anti-neuroinflammatory components of Modified Wuziyanzong Prescription through a target-directed molecular docking fingerprint strategy. Journal of Pharmaceutical and Biomedical Analysis156, 328-339.
[21] Ruby, P. K., Pathak, S. M., & Aggarwal, D. (2014). Critical attributes of transdermal drug delivery system (TDDS)–a generic product development review. Drug development and industrial pharmacy40(11), 1421-1428.
[22] Neumann, P. J. (2021). Toward better data dashboards for US drug value assessments. Value in Health24(10), 1484-1489.
[23] Gondo, G. C., Koons, S., Metcalf, C., Bell, S. J., & Mehta, N. N. (2021). Viewing psoriasis as a systemic disease for better health outcomes. JID Innovations1(2).
[24] Liu, X., Liu, D., Pan, Y., & Li, Y. (2020). Pharmacokinetic/pharmacodynamics variability of echinocandins in critically ill patients: A systematic review and metaanalysis. Journal of Clinical Pharmacy and Therapeutics45(6), 1207-1217.
[25] Munoz, F., Alici, G., & Li, W. (2014). A review of drug delivery systems for capsule endoscopy. Advanced drug delivery reviews71, 77-85.
[26] Shimizu, T., Awata, M., Lila, A. S. A., Yoshioka, C., Kawaguchi, Y., Ando, H., ... & Ishida, T. (2021). Complement activation induced by PEG enhances humoral immune responses against antigens encapsulated in PEG-modified liposomes. Journal of Controlled Release329, 1046-1053.
[27] Pena, S. A., Iyengar, R., Eshraghi, R. S., Bencie, N., Mittal, J., Aljohani, A. & Eshraghi, A. A. (2020). Gene therapy for neurological disorders: challenges and recent advancements. Journal of drug targeting28(2), 111-128.
[28] Kitayama, K., Maeda, S., Nakamura, A., Katayama, I., & Wataya-Kaneda, M. (2019). Efficiency of sirolimus delivery to the skin is dependent on administration route and formulation. Journal of Dermatological Science94(3), 350-353.
[29] Pastore, M. N., Kalia, Y. N., Horstmann, M., & Roberts, M. S. (2015). Transdermal patches: history, development and pharmacology. British journal of pharmacology172(9), 2179-2209.
[30] Wong, W. F., Ang, K. P., Sethi, G., & Looi, C. Y. (2023). Recent advancement of medical patch for transdermal drug delivery. Medicina59(4), 778.
[31] Bargh, J. D., Isidro-Llobet, A., Parker, J. S., & Spring, D. R. (2019). Cleavable linkers in antibody–drug conjugates. Chemical Society Reviews48(16), 4361-4374.
[32] Langer, R. (2004). Transdermal drug delivery: past progress, current status, and future prospects. Adv. Drug. Deliv. Rev.56, 557-558.
[33] Xu, T. (2005). Ion exchange membranes: State of their development and perspective. Journal of membrane science263(1-2), 1-29.
[34] Qin, Y., Zhu, F., Luo, M., & Zhang, L. (2011). Catalystfree preparation of polyhedral oligomeric silsesquioxanes containing Organic–Inorganic hybrid mesoporous nanocomposites. Journal of Applied Polymer Science121(1), 97-101.
[35] Erkan, D. (2021). Expert perspective: management of microvascular and catastrophic antiphospholipid syndrome. Arthritis & Rheumatology73(10), 1780-1790.
[36] Trivedi, J. H. (2013). Synthesis, characterization, and swelling behavior of superabsorbent hydrogel from sodium salt of partially carboxymethylated tamarind kernel powdergPAN. Journal of applied polymer science129(4), 1992-2003.
[37] Johansson, E. M., Ballem, M. A., Córdoba, J. M., & Odén, M. (2011). Rapid synthesis of SBA-15 rods with variable lengths, widths, and tunable large pores. Langmuir, 27(8), 4994-4999.
[38] Hassani, H., Rezanejad, G., & Kharazmi, H. A. (2024). Synthesis and characterization of porous co-polymeric hydrogels of 2-Hydroxyethyl methacrylate and N-vinyl pyrrolidone via high internal phase emulsion. Applied Chemistry Today19(73), 111-122.
[39] Eshaghi Malekshah, R., Salehi, M., & Khaleghian, A. (2016). Synthesis, characterization and comparative study of cytotoxic effect of copper (II) and zinc β-diketonate complexes. Applied Chemistry Today11(41), 165-170.
[40] Nasiri, M., & Abdi, S. (2024). Fabrication and Performance Evaluation of the Polyamide Thin Film Composite Membrane in Desalination and Removal of Naproxen from Aqueous Solutions. Applied Chemistry Today19(72), 339-364.
[41] Rezanejad, G., Pargolghasemi, P., & Banaei, A. (2023). Preparation of new macroporous hydrogel by formation of high internal phase emulsions (HIPEs) template and investigation of controlled release of doxorubicin drug. Applied Chemistry Today18(68), 251-270.
[42] Khanmohammadi, F., Razavi Zadeh, B. M., & Azizi, S. N. (2023). Nanoparticles of SBA-15 synthesized from corn silica as an effective delivery system for valproic acid. Applied Chemistry Today17(65), 65-80.
[43] Azizi, M., Seyed Dorraji, M. S., & Rasoulifard, M. (2018). Preparation of polyurethane nanofibers containing cefixime trihydrate: in vitro release kinetic studies. Applied Chemistry Today13(46), 239-248.