نوع مقاله : مقاله علمی پژوهشی
نویسندگان
1 گروه شیمی- واحد کرمان- دانشگاه آزاد اسلامی-کرمان- ایران
2 دانشگاه آزاد اسلامی واحد کرمان
چکیده
کلیدواژهها
عنوان مقاله [English]
نویسندگان [English]
Introducing new and green methods and finding environmentally friendly solvents in the synthesis of organic compounds is very important. In this study, the synthesis of [1,3] dithiine derivatives using the glycerol: potassium carbonate as deep eutectic solvent was investigated, in addition, the antibacterial effects of the synthesized compounds against two bacterial strains named Edwardsiella tarda and Lactococcus garvieae according to the CLSI standard using microdilution broth base on inhibition zone diameter (IZD), minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were tested. The results showed that glycerol: potassium carbonate could be used as a green solvent in the synthesis of [1,3] dithiine derivatives and the results of antibacterial activities against study also showed that these compounds, especially f5, were capable of inhibiting Edwardsiella tarda and Lactococcus garvieae at concentrations of 64 and 8 μg / ml, respectively. In addition, it was demonstrated that there was a clear relationship between the structure of the derivatives and the antibacterial activity, with the highest effect being on the chlorine-containing compounds, followed by chlorine, bromine, and nitrogen.
کلیدواژهها [English]
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